Fallout new vegas crashing on startup

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I have put probably 400+ hours into NV so that could be the cause? I haven't a clue so help any one. Any how, I was just curious if it does this because my copy has been played a lot.

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Other times it freezes after a few hours of game play. It is not always after a certain amount of time, sometimes it tends to freeze after roughly half an hour.

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Almost every time I play NV my game freezes on me.